REACTIVE & FUNCTIONAL POLYMERS(英文缩写 REACT FUNCT POLYM ),ISSN 1381-5148 ,eISSN 1873-166X ,中文译名: 反应性与功能性聚合物 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。 发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。 Reactive & Functional Polymers 是一本聚焦反应性与功能性高分子材料的国际期刊，涵盖合成、改性、表征及其在分离、催化、传感、生物医学和能源等领域的应用。读者群包括高分子化学、材料科学与化工领域的研究人员与工程师，强调分子设计与性能之间的关联，适合关注功能聚合物从基础到应用转化的科研人员。 主要方向包括功能高分子的合成与修饰、反应性聚合物载体、智能响应材料、高分子催化剂、吸附与分离树脂、生物医用高分子及能源相关聚合物。论文类型以原创研究为主，兼有综述，也接受短通讯，强调材料设计、机理与性能验证。 研究取向偏重功能导向与结构—性能关系，要求合成路线清晰、表征充分并展示明确应用潜力。论文通常兼具化学创新与工程价值，适合高分子合成、材料改性与应用开发领域的研究生和科研人员阅读与投稿。 投稿难度中等偏上，期刊对创新性和数据完整性要求较高，功能应用需有说服力。建议突出分子设计思路与对比实验，补充稳定性、机理或应用验证数据，并注意英文表达与图表规范，不宜仅凭分区判断录用难易。 REACTIVE & FUNCTIONAL POLYMERS 最新收录文献 JCR分区: Q1 CAS分区: B3 影响因子: 5.4 1. Molecularly Imprinted Micelles for Fluorescent Sensing of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). PMID : 33716552 作者 : Likun Duan, Yan Zhao 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2020.104759 日期 : 2020-10-18 Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used over-the-counter drugs and their uncontrolled disposal is a significant environmental concern. Although their fluorescent sensing is a desirable method of detection for its sensitivity and simplicity, the structural similarity of the drugs makes the design of selective sensors highly challenging. A thiourea-based fluorescent functional monomer was identified in this work to enable highly efficient synthesis of molecularly imprinted nanoparticle (MINP) sensors for NSAIDs such as Indomethacin or Tolmetin. Micromolar binding affinities were obtained in aqueous solution, with binding selectivities comparable to those reported for polyclonal antibodies. The detection limit was ~50 ng/mL in aqueous solution, and common carboxylic acids such as acetic acid, benzoic acid, and citric acid showed negligible interference. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 1. Molecularly Imprinted Micelles for Fluorescent Sensing of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used over-the-counter drugs and their uncontrolled disposal is a significant environmental concern. Although their fluorescent sensing is a desirable method of detection for its sensitivity and simplicity, the structural similarity of the drugs makes the design of selective sensors highly challenging. A thiourea-based fluorescent functional monomer was identified in this work to enable highly efficient synthesis of molecularly imprinted nanoparticle (MINP) sensors for NSAIDs such as Indomethacin or Tolmetin. Micromolar binding affinities were obtained in aqueous solution, with binding selectivities comparable to those reported for polyclonal antibodies. The detection limit was ~50 ng/mL in aqueous solution, and common carboxylic acids such as acetic acid, benzoic acid, and citric acid showed negligible interference. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 2. Step-growth Production of Nanogels for Use as Macromers with Dimethacrylate Monomers. PMID : 30636923 作者 : Guangzhe Gao, Parag K Shah, Tao Liu, Jeffery W Stansbury 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2018.11.003 日期 : 2018-11-10 A series of functional nanogels were synthesized by a step-growth mechanism that involved diisocyanate addition to a modest stoichiometric excess of multi-thiols. Nanogels with sizes less than 10 nm were obtained as room temperature liquids with residual thiol groups used to attach methacrylate functionality. Depending on nanogel structure, bulk nanogel properties varied widely, as did the properties of the nanogel-derived and nanogel-modified polymers. Photopolymerization of the reactive nanogels in combination with a dimethacrylate monomer showed dramatically enhanced reaction rate and conversion compared with the dimethacrylate homopolymer. Polymerization shrinkage/ stress as well as mechanical properties of the polymer networks were controlled by changing the ratio of nanogels and dimethacrylate monomers used in formulations. Thus, this study shows the potential of step-growth nanogels for beneficial changes in resin reactivity and application-based performance. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 2. Step-growth Production of Nanogels for Use as Macromers with Dimethacrylate Monomers. A series of functional nanogels were synthesized by a step-growth mechanism that involved diisocyanate addition to a modest stoichiometric excess of multi-thiols. Nanogels with sizes less than 10 nm were obtained as room temperature liquids with residual thiol groups used to attach methacrylate functionality. Depending on nanogel structure, bulk nanogel properties varied widely, as did the properties of the nanogel-derived and nanogel-modified polymers. Photopolymerization of the reactive nanogels in combination with a dimethacrylate monomer showed dramatically enhanced reaction rate and conversion compared with the dimethacrylate homopolymer. Polymerization shrinkage/ stress as well as mechanical properties of the polymer networks were controlled by changing the ratio of nanogels and dimethacrylate monomers used in formulations. Thus, this study shows the potential of step-growth nanogels for beneficial changes in resin reactivity and application-based performance. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 3. {"_":"-forming hyaluronic acid hydrogel through visible light-induced thiol-ene reaction.","i":["In situ"]} PMID : 32256185 作者 : Hyun Jong Lee, Gabriella M Fernandes-Cunha, David Myung 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2018.06.010 日期 : 2018-07-02 Here we present hyaluronic acid (HA) hydrogels crosslinked via thiol-ene reaction initiated by visible blue light exposure in the presence of riboflavin phosphate (RFP). The gelation procedure is rapid and proceeds as effectively with exposure to blue light as it does with UV light. We successfully initiated the thiol-ene reaction by RFP with blue light, which triggered gelation that proceeds over about 5 min at 36 °C after an initial small change in modulus upon light exposure. Gel transparency was also evaluated, and the HA gel exhibited over 80% transmittance in the visible spectrum. The degradation and protein release kinetics of the photo-crosslinked HA hydrogel are also presented. The capacity of blue light to initiate thiol-ene reaction was equal to or more effective than UV light of the same energy. The cytocompatibility of hydrogels was evaluated using corneal fibroblasts, and the light-induced fabrication procedure and resultant gel materials did not affect cell viability. The results indicate that an RFP-based, BL-initiated photo-reaction to gelate HA may be an effective and promising modality for applications where gelation is desired. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 3. {"_":"-forming hyaluronic acid hydrogel through visible light-induced thiol-ene reaction.","i":["In situ"]} Here we present hyaluronic acid (HA) hydrogels crosslinked via thiol-ene reaction initiated by visible blue light exposure in the presence of riboflavin phosphate (RFP). The gelation procedure is rapid and proceeds as effectively with exposure to blue light as it does with UV light. We successfully initiated the thiol-ene reaction by RFP with blue light, which triggered gelation that proceeds over about 5 min at 36 °C after an initial small change in modulus upon light exposure. Gel transparency was also evaluated, and the HA gel exhibited over 80% transmittance in the visible spectrum. The degradation and protein release kinetics of the photo-crosslinked HA hydrogel are also presented. The capacity of blue light to initiate thiol-ene reaction was equal to or more effective than UV light of the same energy. The cytocompatibility of hydrogels was evaluated using corneal fibroblasts, and the light-induced fabrication procedure and resultant gel materials did not affect cell viability. The results indicate that an RFP-based, BL-initiated photo-reaction to gelate HA may be an effective and promising modality for applications where gelation is desired. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 4. {"_":"Tuning Properties of Poly(ethylene glycol)--poly(simvastatin) Copolymers Synthesized via Triazabicyclodecene.","i":["block"]} PMID : 29217967 作者 : Theodora A Asafo-Adjei, Thomas D Dziubla, David A Puleo 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2017.07.004 日期 : 2017-07-27 Simvastatin was polymerized into copolymers to better control drug loading and release for therapeutic delivery. When using the conventional stannous octoate catalyst in ring-opening polymerization (ROP), reaction temperatures ≥200 °C were required, which promoted uncontrollable and undesirable side reactions. Triazabicyclodecene (TBD), a highly reactive guanidine base organocatalyst, was used as an alternative to polymerize simvastatin. Polymerization was achieved at 150 °C using 5 kDa methyl-terminated poly(ethylene glycol) (mPEG) as the initiator. ROP reactions with 2 kDa or 550 Da mPEG initiators were also successful using TBD at 150 °C instead of stannous octoate, which required a higher reaction temperature. Biodegradability of the poly(simvastatin) copolymer in phosphate-buffered saline was also improved, losing twice as much mass than the copolymer synthesized via stannous octoate. The three copolymers exhibited modified rates of simvastatin release, demonstrating tunablity for drug delivery applications. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 4. {"_":"Tuning Properties of Poly(ethylene glycol)--poly(simvastatin) Copolymers Synthesized via Triazabicyclodecene.","i":["block"]} Simvastatin was polymerized into copolymers to better control drug loading and release for therapeutic delivery. When using the conventional stannous octoate catalyst in ring-opening polymerization (ROP), reaction temperatures ≥200 °C were required, which promoted uncontrollable and undesirable side reactions. Triazabicyclodecene (TBD), a highly reactive guanidine base organocatalyst, was used as an alternative to polymerize simvastatin. Polymerization was achieved at 150 °C using 5 kDa methyl-terminated poly(ethylene glycol) (mPEG) as the initiator. ROP reactions with 2 kDa or 550 Da mPEG initiators were also successful using TBD at 150 °C instead of stannous octoate, which required a higher reaction temperature. Biodegradability of the poly(simvastatin) copolymer in phosphate-buffered saline was also improved, losing twice as much mass than the copolymer synthesized via stannous octoate. The three copolymers exhibited modified rates of simvastatin release, demonstrating tunablity for drug delivery applications.

JCR分区: Q1 CAS分区: B3 影响因子: 5.4 5. Surface modification of a polyethylene film for anticoagulant and anti-microbial catheter. PMID : 26900340 作者 : Yingying Zheng, Jianjun Miao, Fuming Zhang, Chao Cai, Amanda Koh, Trevor J Simmons, Shaker A Mousa, Robert J Linhardt 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2016.01.013 日期 : 2016-03-01 A functional anticoagulant and anti-bacterial coating for polyethylene (PE) films is described. The stepwise preparation of this nanocomposite surface coating involves O plasma etching of PE film, carbodiimide coupling of cysteamine to the etched PE film, binding of Ag to sulfhydryl groups of cysteamine, and assembly of heparin capped AgNPs on the PE film. The nanocomposite film and its components were characterized by H-nuclear magnetic resonance spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and field emission-scanning electron microscopy. The resulting PE films demonstrate anticoagulant activity using a hemoglobin whole blood clotting assay, and anti-bacterial activity against 3551 (Gram-positive) and BL21 (Gram-negative) bacteria. The hydrophilicity of the heparin coated PE was determined by contact angle measurements; and the stability of the nanocomposite film, with respect to Ag leaching, was assessed by atomic absorption spectroscopy. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 5. Surface modification of a polyethylene film for anticoagulant and anti-microbial catheter. A functional anticoagulant and anti-bacterial coating for polyethylene (PE) films is described. The stepwise preparation of this nanocomposite surface coating involves O plasma etching of PE film, carbodiimide coupling of cysteamine to the etched PE film, binding of Ag to sulfhydryl groups of cysteamine, and assembly of heparin capped AgNPs on the PE film. The nanocomposite film and its components were characterized by H-nuclear magnetic resonance spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and field emission-scanning electron microscopy. The resulting PE films demonstrate anticoagulant activity using a hemoglobin whole blood clotting assay, and anti-bacterial activity against 3551 (Gram-positive) and BL21 (Gram-negative) bacteria. The hydrophilicity of the heparin coated PE was determined by contact angle measurements; and the stability of the nanocomposite film, with respect to Ag leaching, was assessed by atomic absorption spectroscopy. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 6. Bioreducible polymers for gene delivery. PMID : 21516195 作者 : Tae-Il Kim, Sung Wan Kim 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2010.11.016 日期 : 2011-03-01 Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as decreased cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. This review will describe the initiation and recent advances in the development of bioreducible polymers for gene delivery, which includes reducibly cross-linked PEIs, polypeptides, polyion complex micelles, and poly(amido amine)s. There have been extensive researches performed to exhibit great gene delivery efficacy but still several important issues about pharmacokinetics or safety should be answered thoroughly for further rational design of bioreducible polymers having potentials in human gene delivery systems. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 6. Bioreducible polymers for gene delivery. Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as decreased cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. This review will describe the initiation and recent advances in the development of bioreducible polymers for gene delivery, which includes reducibly cross-linked PEIs, polypeptides, polyion complex micelles, and poly(amido amine)s. There have been extensive researches performed to exhibit great gene delivery efficacy but still several important issues about pharmacokinetics or safety should be answered thoroughly for further rational design of bioreducible polymers having potentials in human gene delivery systems. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 7. Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery. PMID : 21503276 作者 : Nataliya V Nukolova, Zigang Yang, Jong Oh Kim, Alexander V Kabanov, Tatiana K Bronich 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2010.10.011 日期 : 2011-03-01 Novel surface-functionalized cross-linked nanogels were developed as a platform to allow conjugation of monoclonal antibodies (mAb) for targeted drug delivery. Well-defined diblock copolymers of poly(ethylene glycol)-b-poly(methacrylic acid) (PEG-b-PMA) with PEG terminal aldehyde functionality were synthesized by atom transfer radical polymerization (ATRP) and characterized by GPC and (1)H NMR. These copolymers were used to prepare nanogels via condensation of PEG-b-PMA with Ca(2+) ions into micelle-like aggregates, cross-linking of the PMA/Ca(2+) cores and removal of Ca(2+) ions. The resulting nanogels represent highly swollen spherical polyelectrolyte particles with free terminal aldehyde functionalities at the nonionic PEG chains. A reductive amination reaction between aldehyde groups and amino groups of mAb resulted in effective conjugation to the nanogels of mAb CC49 against tumor-associated glycoprotein 72 (TAG-72). The mAb retained the binding affinity to bovine submaxillary mucin after conjugation as shown by surface plasmon resonance (SPR). Therefore, aldehyde functionalized nanogels can be linked to mAb using a simple, one-step approach. They may have potential for targeted delivery of diagnostic and therapeutic agents to tumors. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 7. Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery. Novel surface-functionalized cross-linked nanogels were developed as a platform to allow conjugation of monoclonal antibodies (mAb) for targeted drug delivery. Well-defined diblock copolymers of poly(ethylene glycol)-b-poly(methacrylic acid) (PEG-b-PMA) with PEG terminal aldehyde functionality were synthesized by atom transfer radical polymerization (ATRP) and characterized by GPC and (1)H NMR. These copolymers were used to prepare nanogels via condensation of PEG-b-PMA with Ca(2+) ions into micelle-like aggregates, cross-linking of the PMA/Ca(2+) cores and removal of Ca(2+) ions. The resulting nanogels represent highly swollen spherical polyelectrolyte particles with free terminal aldehyde functionalities at the nonionic PEG chains. A reductive amination reaction between aldehyde groups and amino groups of mAb resulted in effective conjugation to the nanogels of mAb CC49 against tumor-associated glycoprotein 72 (TAG-72). The mAb retained the binding affinity to bovine submaxillary mucin after conjugation as shown by surface plasmon resonance (SPR). Therefore, aldehyde functionalized nanogels can be linked to mAb using a simple, one-step approach. They may have potential for targeted delivery of diagnostic and therapeutic agents to tumors. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 8. Efficient Intracellular Delivery of a Pro-Apoptotic Peptide With A pH-Responsive Carrier. PMID : 21499545 作者 : Brian Albarran, Allan S Hoffman, Patrick S Stayton 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2010.09.008 日期 : 2011-03-01 A key challenge in developing protein therapeutics or imaging agents that work against cytosolic targets is the intracellular delivery barrier. Here, we show that the pH-responsive, membrane-destabilizing polymer, poly (propylacrylic acid) (PPAA), can strongly enhance target cell killing through the intracellular delivery of a functional proapoptotic peptide. The Bak BH3 peptide induces apoptosis via antagonization of suppressor targets such as Bcl-2 and Bcl-x(L). A genetically-engineered streptavidin that contains an N-terminal TAT peptide sequence was used to optimize the pinocytotic cell uptake of biotinylated BH3 peptide and end-biotinylated PPAA. Fluorescence microscopic analysis of DAPI-stained HELA cells was used to quantitate apoptosis. Approximately 30% of cells treated with TAT-SA:BH3 complexes revealed morphologically distinct nuclear condensation, a hallmark of apoptosis. The incorporation of biotinylated PPAA had the effect of markedly enhancing the killing effect of BH3 peptides by an additional 55% (p<0.001) to a total cell killing efficiency of 85%. Caspase-3 activity was up-regulated in a TAT-SA:BH3:PPAA dose-dependent manner. The induction of apoptosis with the TAT-SA:BH3:PPAA complex was abrogated with the L78A BH3 peptide, that had been previously shown to knock-out antagonization activity. The caspase and L78A peptide results demonstrate that the delivered BH3 is indeed working through the biologically relevant apoptosis signaling pathway. These studies establish the ability of PPAA to strongly enhance the intracellular delivery of a functional pro-apoptotic peptide. Together with the PPAA, the TAT-SA adaptor complex could prove useful as a carrier of peptide/protein cargo to cultured cells. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 8. Efficient Intracellular Delivery of a Pro-Apoptotic Peptide With A pH-Responsive Carrier. A key challenge in developing protein therapeutics or imaging agents that work against cytosolic targets is the intracellular delivery barrier. Here, we show that the pH-responsive, membrane-destabilizing polymer, poly (propylacrylic acid) (PPAA), can strongly enhance target cell killing through the intracellular delivery of a functional proapoptotic peptide. The Bak BH3 peptide induces apoptosis via antagonization of suppressor targets such as Bcl-2 and Bcl-x(L). A genetically-engineered streptavidin that contains an N-terminal TAT peptide sequence was used to optimize the pinocytotic cell uptake of biotinylated BH3 peptide and end-biotinylated PPAA. Fluorescence microscopic analysis of DAPI-stained HELA cells was used to quantitate apoptosis. Approximately 30% of cells treated with TAT-SA:BH3 complexes revealed morphologically distinct nuclear condensation, a hallmark of apoptosis. The incorporation of biotinylated PPAA had the effect of markedly enhancing the killing effect of BH3 peptides by an additional 55% (p<0.001) to a total cell killing efficiency of 85%. Caspase-3 activity was up-regulated in a TAT-SA:BH3:PPAA dose-dependent manner. The induction of apoptosis with the TAT-SA:BH3:PPAA complex was abrogated with the L78A BH3 peptide, that had been previously shown to knock-out antagonization activity. The caspase and L78A peptide results demonstrate that the delivered BH3 is indeed working through the biologically relevant apoptosis signaling pathway. These studies establish the ability of PPAA to strongly enhance the intracellular delivery of a functional pro-apoptotic peptide. Together with the PPAA, the TAT-SA adaptor complex could prove useful as a carrier of peptide/protein cargo to cultured cells. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 9. Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates. PMID : 21499527 作者 : Jiyuan Yang, Kui Luo, Huaizhong Pan, Pavla Kopečková, Jindřich Kopeček 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2010.10.005 日期 : 2011-03-01 A new strategy for the synthesis of biodegradable high molecular weight N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymeric carriers has been designed. An enzyme-sensitive, alkyne-functionalized, chain transfer agent (CTA-GFLG-alkyne; N(α)-(4-pentynoyl)-N(δ)-(4-cyano-4-(phenylcarbonothioylthio)pentanoyl-glycylphenylalanylleucylglycyl)-lysine) was synthesized and used to mediate the reversible addition-fragmentation chain-transfer (RAFT) polymerization and copolymerization of HPMA. Post-polymerization modification with 4,4'-azobis(azidopropyl 4-cyanopentanoate)resulted in the formation of heterotelechelic HPMA copolymers containing terminal alkyne and azide groups. Chain extension via click reaction resulted in high molecular weight multiblock copolymers. Upon exposure to papain, these copolymers degraded into the initial blocks. Similar results were obtained for copolymers of HPMA with N-methacryloylglycylphenylalanylleucylglycyl thiazolidine-2-thione and N-methacryloylglycylphenylalanylleucylglycyl-gemcitabine. The new synthetic method presented permits the synthesis of biocompatible, biodegradable high molecular weight HPMA copolymer-anticancer drug conjugates that possess long-circulation times and augmented accumulation in solid tumor tissue due to the enhanced permeability and retention effect. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 9. Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates. A new strategy for the synthesis of biodegradable high molecular weight N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymeric carriers has been designed. An enzyme-sensitive, alkyne-functionalized, chain transfer agent (CTA-GFLG-alkyne; N(α)-(4-pentynoyl)-N(δ)-(4-cyano-4-(phenylcarbonothioylthio)pentanoyl-glycylphenylalanylleucylglycyl)-lysine) was synthesized and used to mediate the reversible addition-fragmentation chain-transfer (RAFT) polymerization and copolymerization of HPMA. Post-polymerization modification with 4,4'-azobis(azidopropyl 4-cyanopentanoate)resulted in the formation of heterotelechelic HPMA copolymers containing terminal alkyne and azide groups. Chain extension via click reaction resulted in high molecular weight multiblock copolymers. Upon exposure to papain, these copolymers degraded into the initial blocks. Similar results were obtained for copolymers of HPMA with N-methacryloylglycylphenylalanylleucylglycyl thiazolidine-2-thione and N-methacryloylglycylphenylalanylleucylglycyl-gemcitabine. The new synthetic method presented permits the synthesis of biocompatible, biodegradable high molecular weight HPMA copolymer-anticancer drug conjugates that possess long-circulation times and augmented accumulation in solid tumor tissue due to the enhanced permeability and retention effect. JCR分区: Q1 CAS分区: B3 影响因子: 5.4 10. Biguanide-, imine-, and guanidine- based networks as catalysts for transesterification of vegetable oil. PMID : 20495678 作者 : Lev Bromberg, Ezio Fasoli, Michael Alvarez, T Alan Hatton, Gabriel L Barletta 期刊 : Reactive & functional polymers PubMed DOI : 10.1016/j.reactfunctpolym.2010.04.003 日期 : 2010-05-25 Polycationic systems based on poly(hexamethylene biguanide) (PHMBG), branched polyethyleneimine (PEI) and poly(N-vinylguanidine) (PVG) have been evaluated as heterogeneous catalysts for the transesterification of sunflower oil by methanol. Insoluble networks are synthesized via crosslinking of PHMBG by either 4,4'-methylenebis(N,N-diglycidylaniline) or polyisocyanate prepolymer, PEI with sebacoyl chloride, and PVG with 1,4-butanediol diglycidyl ether. PHMBG and its crosslinked networks appeared to be remarkably efficient catalysts, enabling 80-100% triglyceride conversion within 0.5 h at 70 degrees C. PEI-based networks catalyzed triglyceride transesterification with rates 8- to 12-fold slower than their PHMBG-based counterparts. The PVG-based networks, which were devoid of hydrophobic moieties, appeared to be inefficient catalysts due to limited accessibility of the basic guanidine groups to reactants. The PHMBG networks were shown to be recyclable by a simple centrifugal filtration. After 15 cycles of recovery and reuse, only 10-15% decline in performance was observed. 展开全文 收起 获取 PDF 原文 查看详情 PubMed 原文记录 10. Biguanide-, imine-, and guanidine- based networks as catalysts for transesterification of vegetable oil. Polycationic systems based on poly(hexamethylene biguanide) (PHMBG), branched polyethyleneimine (PEI) and poly(N-vinylguanidine) (PVG) have been evaluated as heterogeneous catalysts for the transesterification of sunflower oil by methanol. Insoluble networks are synthesized via crosslinking of PHMBG by either 4,4'-methylenebis(N,N-diglycidylaniline) or polyisocyanate prepolymer, PEI with sebacoyl chloride, and PVG with 1,4-butanediol diglycidyl ether. PHMBG and its crosslinked networks appeared to be remarkably efficient catalysts, enabling 80-100% triglyceride conversion within 0.5 h at 70 degrees C. PEI-based networks catalyzed triglyceride transesterification with rates 8- to 12-fold slower than their PHMBG-based counterparts. The PVG-based networks, which were devoid of hydrophobic moieties, appeared to be inefficient catalysts due to limited accessibility of the basic guanidine groups to reactants. The PHMBG networks were shown to be recyclable by a simple centrifugal filtration. After 15 cycles of recovery and reuse, only 10-15% decline in performance was observed. 在 REACTIVE & FUNCTIONAL POLYMERS 中搜索更多文献